Think long term is definitely the way forward for projects that you believe will be game changers, but as someone mentioned above, there is no harm in taking profits along the way. Don't just blindly hold without analysing why you are doing it. Keeping track of your portfolio on a regular basis is essential if you want to maximise your profits. That way there will be possibilities to either increase your holding by selling and buying back in at a lower price, taking clear profit and reinvesting elsewhere, or selling portions to decrease risk. Each coin should have a different strategy, and even that should be adapted as the market changes.