Roll the dice and take your chances, but as has been mentioned already, I think you'd be silly to ignore the big players. Holding 60% of your portfolio in Bitcoin and Ethereum would be the sensible move, maybe 20% in Neo and Litecoin, then 20% spread over another 5-8 coins. That way you're spreading your risk, but still have the potential to make some decent money. For the record, my 5-8 coins (or tokens) would include at least some of the following: Monetha, Divi, Golem, Safex, Substratum, Chainlink and Stratis. They cover a broad spectrum of industry between them, and some are obviously more high risk than others, but that's why the variety is there.