Heheh profits? You're asking the question at the wrong time; however, if it is worthy of an answer, it would have to be the biggest coins with the most volatility, as volatility is the key factor that will enable you to make profits...so obviously Ethereum, LiteCoin, BitCoin Cash, EoS etc... There has just been a useful spike in altcoins lately which was provoked I'm not sure by what but possibly might have been just a backlash from the previous falling prices I don't know...but you can take your opportunities whenever any of these nice, established coins goes up a bit - Altcoin season was 2017-2018 and now, it's not sure which ones are worthwhile investing in from the upcoming newcoins?.. But it's definitely way past season to be putting your faith in many of the coins that are further down the list. And you should look on coinmarketcap.com switching to Volume if you want to find out what are the biggest volume coins.
Just an extra bit, I notice Tether at the top of the Volume ratings but, is it really that profitable given the tiny changes in price that we seem to be getting?