If you're a bitcoiner and have the intention of making huge bitcoin transaction from one wallet to another, the you may have to make use of a bitcoin mixer, the reason for this is on privacy, you will not have to pass through the use of an exchange
It is not really about the amount in BTC, it is simply that you want to obscure the origin of your coin, even if it is a small amount in BTC. Mixers are very easy to use and the fees are not so high, so you don't have to make a large tx before you use a mixer.
Mixers do not substitute an exchange, even after using a mixer, if you want to trade your coins, you still have to do so in an exchange, but preferably a p2p exchange.