Yes and no.
Yes if you are holding Bitcoin and Ethereum. They are worth holding in the long run because of their massive adoption, real use cases, fundamentals, trading volume, market cap, etc.
No if we’re talking about other altcoins. They’re not worthy to hold in the long term. Maybe for short term basis yes like BNB, MATIC, AVAX, SOL, etc. The rest well it’s all about getting lucky to profit after ICO, IDO, IEO, etc.