The most important thing is to know what you're getting in to. Research the coin and see if it's worth holding, this way you remove the risk of unexpected price crashes.
I'm trading mostly major coins but also started to trade VEIL, which is a small privacy coin. It's the only new coin I'm trading because it has the ability to do really well so I'm not worried about an unknown crash. There was no ICO and that means no big private sale investors with 90% discount on token price that I need to fear a dump from. There is no premine so I don't need to worry about founder dumping on me. The supply can be audited so all the information is verifiable.