Honestly speaking government regulation on cryptocurrency is the biggest setback to decentralization, However I am very optimistic that cryptocurrency will survive regulations no matter the effort by government to control crypto at their own will.
One solution, in my opinion, is Anonymity.
Government efforts on regulation has proven very difficult to outrightly regulate because there are still anonymous coins transactions that are still moving in line with decentralized plans of cryptocurrency, though government are trying to tag them as security. What ever effort government makes, I think decentralization will not be completely eroded off because many projects will venture into Anonymity options.
In addition, as government is pushing to kill decentralization, so also the crypto experts will always come up with alternative ideas to keep the ecosystem on the decentralized core plans.