If you are looking for the safest wallet to secure your assets, I recommend to use hardware wallets, that is always the best choice. However, only few can afford hardware wallets that's why many of us are using hot wallet. Hot wallet is also safe but still vulnerable to hacking, and viruses. You have to be careful when you are using this type of wallet because simple mistake can lead to loss of assets. I'm using a hot wallet for a long time now, I experienced hacking but I learned from it and never again experienced being hacked.