This weekend we might see some changes at the top. The leader, Barcelona, is playing away against the 3rd Atletico, while 2nd Real is playing away against 5th Villareal.
The odds are:
Atletico: x3.20
Barca: x2.16
Villareal: x3.00
Real: x2.20
I think there's a big chance Barcelona could lose points in Madrid, although they tend to perform equally good at home and away, Atletico played really well against Real in the UCL yesterday and won't be easy to defeat.
On the other hand, Real has a strong tendency to perform better at home, their average points-per-game ratio is almost 1 point higher for home games. So they might struggle against a solid team like Villareal.
Things might get interesting.